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Hormonal disorders occur when the body produces too much or too little of a hormone, or stops responding properly to hormones. Hormones are chemical messengers that regulate many bodily functions, including metabolism, blood sugar, growth, and mood. Some common symptoms of hormonal disorders include: Darkening of the skin, Skin tags, Weight changes, Lower sex drive, and Acne. Some common causes of hormonal disorders include: Exposure to certain chemicals in the environment The reproductive system The thyroid Tumors Certain medications Chromosomal defects Inflammation Autoimmune disease Some examples of hormonal disorders include: Diabetes: The most common hormonal disorder in the United States Polycystic ovary syndrome (PCOS): A leading cause of infertility Cushing's disease: A hormonal disorder with a wide range of symptoms Adrenal insufficiency: An underactive adrenal gland produces insufficient cortisol hormone Hyperthyroidism: The thyroid gland makes too many thyroid hormones Hypothyroidism: The thyroid gland does not make enough thyroid hormones